Year 2019, Volume 6, Issue 1, Pages 38 - 48 2019-03-16

Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes

Hülya Çelik [1] , Aynur Babagil [2]

15 127

In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4-nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4-fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized. The structures of the synthesized compounds were characterized by Fouirer Transform İnfrared Spektrofotometre (FTIR spectroscopy), Nuclear Magnetic Resonance (NMR spectroscopy) and elemental analysis methods. The prepared compounds were tested for their inhibitory effects on carbonic anhydrase isoenzymes (hCA-I and hCA-II). The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro. By testing these compounds in other CA isoenzymes, more effective CA inhibitors can be formed. Thus, new therapeutic applications can be made for enzyme activators in the near future.
Schiff, microwave, fluoroaniline, nitroaniline
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Primary Language en
Subjects Biology
Published Date March
Journal Section Articles
Authors

Orcid: 0000-0003-0805-0523
Author: Hülya Çelik (Primary Author)
Institution: AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ
Country: Turkey


Author: Aynur Babagil
Institution: ATATURK UNIVERSITY
Country: Turkey


Bibtex @research article { ijsm479108, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {İzzet KARA}, year = {2019}, volume = {6}, pages = {38 - 48}, doi = {10.21448/ijsm.479108}, title = {Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes}, key = {cite}, author = {Çelik, Hülya and Babagil, Aynur} }
APA Çelik, H , Babagil, A . (2019). Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes. International Journal of Secondary Metabolite, 6 (1), 38-48. DOI: 10.21448/ijsm.479108
MLA Çelik, H , Babagil, A . "Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes". International Journal of Secondary Metabolite 6 (2019): 38-48 <http://ijsm.ijate.net/issue/41604/479108>
Chicago Çelik, H , Babagil, A . "Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes". International Journal of Secondary Metabolite 6 (2019): 38-48
RIS TY - JOUR T1 - Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes AU - Hülya Çelik , Aynur Babagil Y1 - 2019 PY - 2019 N1 - doi: 10.21448/ijsm.479108 DO - 10.21448/ijsm.479108 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 38 EP - 48 VL - 6 IS - 1 SN - -2148-6905 M3 - doi: 10.21448/ijsm.479108 UR - https://doi.org/10.21448/ijsm.479108 Y2 - 2019 ER -
EndNote %0 International Journal of Secondary Metabolite Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes %A Hülya Çelik , Aynur Babagil %T Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes %D 2019 %J International Journal of Secondary Metabolite %P -2148-6905 %V 6 %N 1 %R doi: 10.21448/ijsm.479108 %U 10.21448/ijsm.479108
ISNAD Çelik, Hülya , Babagil, Aynur . "Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes". International Journal of Secondary Metabolite 6 / 1 (March 2019): 38-48. https://doi.org/10.21448/ijsm.479108