Year 2019, Volume 6, Issue 2, Pages 211 - 222 2019-07-15

Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson

Aybeniz Yıldırım [1] , Ali Şen [2] , Ahmet Doğan [3] , Leyla Bitis [4]

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In this study, various extracts obtained different parts of Tanacetum cilicicum were investigated for in vitro antioxidant and anti-inflammatory activity. Antioxidant activity was tested with three methods; namely 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, 2.2′‐azinobis (3‐ethylbenzothiazolin‐6‐sulphonic acid) (ABTS) radical cation scavenging capacity, and ferric-reducing antioxidant power (FRAP) assays. Total phenolic and flavonoid contents of extracts were determined by Folin-Ciocalteu and aluminum chloride methods, respectively. Also, anti-inflammatory activity of these extracts was evaluated by 5-lipoxygenase inhibition assay. Ethyl acetate extract of capitula of T. cilicicum (TCCEA) showed the highest antioxidant activity with IC50 values of 22.44 and 30.86 µg/mL against DPPH and ABTS radicals, respectively. At the same time, the highest ferric reducing power was found in the TCCEA (42.2 mg TE/g extract). The highest total phenolic contents have been detected in TCCEA and ethyl acetate extract of leaves of T. cilicicum (TCLEA) with value of 174.1 and 175.6 mg GAE/g extract, respectively. Similarly, the highest total flavonoid contents have been detected in TCCEA and TCLEA with values of 26.94 and 30.48 mg QE/g extract, respectively. TCCEA exhibited strong anti-inflammatory activity with IC50 value of 9.44 µg/mL when compared to standard indomethacine (22.39 µg/mL). These results demonstrate that TCCEA has a significant antioxidant and anti-inflammatory activity. Also, the results show that TCCEA is a good candidate for further bioactivity-guided fractionation in the search for new active anti-inflammatory and antioxidant compounds.
Tanacetum cilicicum, Anti-inflammatory activity, Antioxidant activity, Total phenol content
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Primary Language en
Subjects Biology
Published Date June
Journal Section Articles
Authors

Orcid: 0000-0002-5801-4726
Author: Aybeniz Yıldırım
Institution: MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Orcid: 0000-0002-2144-5741
Author: Ali Şen (Primary Author)
Institution: MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Orcid: 0000-0003-0603-5100
Author: Ahmet Doğan
Institution: MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Orcid: 0000-0003-1167-6666
Author: Leyla Bitis
Institution: MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Dates

Publication Date: July 15, 2019

Bibtex @research article { ijsm510316, journal = {International Journal of Secondary Metabolite}, issn = {}, eissn = {2148-6905}, address = {İzzet KARA}, year = {2019}, volume = {6}, pages = {211 - 222}, doi = {10.21448/ijsm.510316}, title = {Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson}, key = {cite}, author = {Yıldırım, Aybeniz and Şen, Ali and Doğan, Ahmet and Bitis, Leyla} }
APA Yıldırım, A , Şen, A , Doğan, A , Bitis, L . (2019). Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson. International Journal of Secondary Metabolite, 6 (2), 211-222. DOI: 10.21448/ijsm.510316
MLA Yıldırım, A , Şen, A , Doğan, A , Bitis, L . "Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson". International Journal of Secondary Metabolite 6 (2019): 211-222 <http://ijsm.ijate.net/issue/44217/510316>
Chicago Yıldırım, A , Şen, A , Doğan, A , Bitis, L . "Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson". International Journal of Secondary Metabolite 6 (2019): 211-222
RIS TY - JOUR T1 - Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson AU - Aybeniz Yıldırım , Ali Şen , Ahmet Doğan , Leyla Bitis Y1 - 2019 PY - 2019 N1 - doi: 10.21448/ijsm.510316 DO - 10.21448/ijsm.510316 T2 - International Journal of Secondary Metabolite JF - Journal JO - JOR SP - 211 EP - 222 VL - 6 IS - 2 SN - -2148-6905 M3 - doi: 10.21448/ijsm.510316 UR - https://doi.org/10.21448/ijsm.510316 Y2 - 2019 ER -
EndNote %0 International Journal of Secondary Metabolite Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson %A Aybeniz Yıldırım , Ali Şen , Ahmet Doğan , Leyla Bitis %T Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson %D 2019 %J International Journal of Secondary Metabolite %P -2148-6905 %V 6 %N 2 %R doi: 10.21448/ijsm.510316 %U 10.21448/ijsm.510316
ISNAD Yıldırım, Aybeniz , Şen, Ali , Doğan, Ahmet , Bitis, Leyla . "Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson". International Journal of Secondary Metabolite 6 / 2 (July 2019): 211-222. https://doi.org/10.21448/ijsm.510316
AMA Yıldırım A , Şen A , Doğan A , Bitis L . Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson. Int. J. Sec. Metabolite. 2019; 6(2): 211-222.
Vancouver Yıldırım A , Şen A , Doğan A , Bitis L . Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson. International Journal of Secondary Metabolite. 2019; 6(2): 222-211.